https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 TLR2-mediated activation of innate responses in the upper airways confers antiviral protection of the lungs https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44978 Wed 26 Oct 2022 08:53:24 AEDT ]]> TLR2-mediated innate immune priming boosts lung anti-viral immunity https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48671 Tue 28 Mar 2023 10:25:49 AEDT ]]> Prophylactic intranasal administration of a TLR2/6 agonist reduces upper respiratory tract viral shedding in a SARS-CoV-2 challenge ferret model https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45262 p=<0.0001) by up to a 24 fold (96% reduction) and in nasal wash (p=0.0107) up to a 15 fold (93% reduction) in comparison to untreated animals. Interpretation: The results of our study support clinical development of a therapy based on prophylactic TLR2/6 innate immune activation in the URT, to reduce SARS-CoV-2 transmission and provide protection against COVID-19.]]> Fri 28 Oct 2022 11:45:44 AEDT ]]>